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Pseudocoptisine chloride
CAS No. 30044-78-1
Pseudocoptisine chloride ( Isocoptisine chloride )
Catalog No. M28939 CAS No. 30044-78-1
Pseudocoptisine chloride is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | Get Quote |
|
| 10MG | 222 | Get Quote |
|
| 25MG | 417 | Get Quote |
|
| 50MG | 615 | Get Quote |
|
| 100MG | 870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePseudocoptisine chloride
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NoteResearch use only, not for human use.
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Brief DescriptionPseudocoptisine chloride is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).
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DescriptionPseudocoptisine chloride is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).(In Vitro):In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions.(In Vivo):Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test.
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SynonymsIsocoptisine chloride
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorVHL
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Research Area——
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Indication——
Chemical Information
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CAS Number30044-78-1
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Formula Weight355.8
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Molecular FormulaC19H14ClNO4
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Purity>98% (HPLC)
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Solubility——
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SMILES[N+]12=CC3=CC4=C(OCO4)C=C3C=C1C5=CC6=C(OCO6)C=C5CC2.[Cl-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
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